ASEA SCIENTIFIC VALIDATION
“ASEA REDOX SUPPLEMENT represents a new health science technology that is 10-15 years ahead of its time”.
Dr Gary Samuelson (Atomic Medical Physicist PhD)
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INDEPENDENT SCIENCE
Since we are bringing a breakthrough technology to the market place, it is important that we have valid independent science to back it up.
Here you will find a sample of some of the science that brings tremendous credibility to our historic breakthrough and the
ASEA REDOX SUPPLEMENT.
Here you will find some of the peer reviewed articles from PubMed, Medical Journals and ASEA.
Links to the original, complete papers are provided.
Stem Cells, Redox Signaling, and Stem Cell Aging
The connection between functional stem cell decline and the loss of tissue homeostasis leads to aging-related diseases.
The connection between functional stem cell decline and the loss of tissue homeostasis leads to aging-related diseases. Recent advances highlight the role of redox metabolism in controlling the stem cell pool and aging. While reactive oxygen species (ROS) are typically known for causing cellular damage, emerging evidence suggests they play a beneficial role in physiological signaling in stem cells. This review focuses on signaling pathways and transcription factors regulated by ROS, influencing stem cell fate and potentially contributing to diseases of stem cell aging. Future research aims to understand how ROS control stem cell cycling, apoptosis, and lineage determination, providing insights into mechanisms underlying stem cell aging.
Nrf2 Mediates Redox Adaptation to Exercise
Exercise boosts our master antioxidant defense system, Nrf2, across various tissues, promoting overall health benefits.
This review explores how exercise impacts a master regulator called Nrf2, which controls many genes for antioxidant defenses. Exercise triggers Nrf2, boosting our body’s ability to fight free radicals. Importantly, Nrf2 activation does not only occur in muscles, but across various tissues, suggesting it plays a key role in exercise’s overall health benefits. Findings from animal studies suggest that Nrf2 activation is a promising area for understanding and maximizing the positive effects of exercise in humans.
Reactive Oxygen Species Signaling Differentially Controls Wound Healing and Regeneration
Reactive oxygen species act as a crucial ‘traffic signal’ to determine whether tissues heal or regenerate, offering potential therapeutic insights for various health challenges.
The ability of organisms to respond to injuries and repair tissues is variable across species and even between different tissues. While some animals can effectively regenerate damaged structures, humans face limitations in renewing tissues, leading to significant health challenges. Flatworms were used as a model to explore the role of reactive oxygen species (ROS) in the healing and regrowth of tissues. Results indicated that ROS play a vital role in controlling gene expression and shaping the outcome of tissue repair. The study identifies a threshold mechanism for ROS signaling – different levels of ROS can activate and regulate specific processes for either tissue repair or regeneration, wound closure and wound-related gene expression. The results highlight the balance of ROS signaling as a potential therapeutic means to control wound repair mechanisms in multiple contexts.
Redox Theory Of Aging
The theory of aging states that aging is the decline of the body’s interconnected redox-dependent systems.
The article Redox Theory of Aging explains that aging is a decline in the interaction between the genome, environmental exposures, and responses of an organism. In this manner, oxidative stress and the imbalance of cellular redox reactions contribute significantly to an accumulative failure of adaptive structures that support the genome-environment interaction. Integrated redox networks ultimately fail due to constant environmental exposure which eventually cannot be sustained by these systems.
Redox Balance in Type 2 Diabetes
Redox Balance in Type 2 Diabetes: Therapeutic Potential and the Challenge of Antioxidant-Based Therapy
Oxidative stress is an important factor in the development of type 2 diabetes (T2D) and associated complications. Unfortunately, most clinical studies have failed to provide sufficient evidence regarding the benefits of antioxidants (AOXs) in treating this disease.
Based on the known complexity of reactive oxygen species (ROS) functions in both the physiology and pathophysiology of glucose homeostasis, it is suggested that inappropriate dosing leads to the failure of AOXs in T2D treatment.
To support this hypothesis, the role of oxidative stress in the pathophysiology of T2D is described, together with a summary of the evidence for the failure of AOXs in the management of diabetes. A comparison of preclinical and clinical studies indicates that suboptimal dosing of AOXs might explain the lack of benefits of AOXs.
Conversely, the possibility that glycemic control might be adversely affected by excess AOXs is also considered, based on the role of ROS in insulin signaling. We suggest that AOX therapy should be given in a personalized manner according to the need, which is the presence and severity of oxidative stress.
With the development of gold-standard biomarkers for oxidative stress, optimization of AOX therapy may be achieved to maximize the therapeutic potential of these agents.
Type 2 Diabetes as a Redox Disease
Increasing synthesis of the transcription factor Nrf2 - Early Lancet Journal by James D. Watson
Physical exercise has long been widely regarded as essential to human health. Yet, we do not know how exercise-stressed skeletal muscle cells that generate reactive oxygen species such as hydrogen peroxide (H2O2) delay—if not prevent—the occurrence and severity of diseases such as type 2 diabetes (as well as dementias, cardiovascular disease, and some cancers). Also unexplained is the recent finding that metformin—the most commonly used drug to treat type 2 diabetes —and physical exercise seem to be beneficial for several of the same diseases, including cancer, Alzheimer's disease, and cardiovascular disease.
New evidence shows that combinations of short-term metformin treatment with single acute bouts of exercise do not, as generally expected, enhance insulin sensitivity. In fact, metformin alone can attenuate much of the oxidative effect of exercise.
The reason why exercise and metformin have opposing physiological consequences (oxidative vs reducing) has been shown by studies
that suggest that giving mice metformin increases synthesis of the transcription factor Nrf2, which controls the downstream synthesis of RNA molecules coding for major cellular antioxidant enzymes.
Hormesis defines the limits of lifespan
Aging is Connected to an Oxidant/Antioxidant Imbalance Leading to Inflammation and Cellular Damage. Organisms Can Adapt to Stress Through a Response called Hormesis, Where Low Stress Levels Trigger Positive Adaptations that can Potentially Lead to a Longer Life
The oxidant/antioxidant imbalance, known as oxidative stress, contributes to the inflammation and cellular degeneration
that leads to aging.
While often seen as negative, oxidative stress is actually necessary
for all living organisms in order to maintain and repair processes, crucial for survival and lifespan.
Hormesis is an adaptive response that helps organisms adapt to oxidative stress. It follows a specific dose-response pattern where a low dose of a stressor stimulates a response, while a high
dose inhibits it.
The key idea is that many positive adaptations, that might support increased lifespan, can occur within this hormetic response. The hormetic response varies from individual, cell type, and mechanism. It is the major controlling framework with which drugs and supplements that enhance biological performance work.
Sirtuins & Neurogenesis
Sirtuins and redox signaling interplay in neurogenesis, neurodegenerative diseases, and neural cell reprogramming
Neural Stem Cells (NSCs) possess the ability to self-renew and, when required, differentiate into various types of nervous system cells. There are molecular pathways that sustain NSC functionality such as the Sirtuin (SIRTs) protein family, specifically SIRT1, SIRT3, and SIRT5, which are involved in the modulation of a variety of cellular processes including neurogenesis and cellular reprogramming.
These processes are involved with antioxidant and redox signaling. They have a role in the metabolic switch in neurogenesis regulation,
via mitochondria metabolism, particularly through
reactive oxygen species and NAD.
A better understanding of the mechanisms governing adult neurogenesis holds the potential to revolutionize the treatment of a wide spectrum of conditions such as neurodegenerative, neuropsychiatric,
and metabolic diseases.
The Role of Nrf2 in Pulmonary Fibrosis
Pulmonary fibrosis is a lung disease and a global health issue.
Pulmonary fibrosis is a lung disease and a global health issue. Despite advances in the understanding of this disease, there are still no effective methods in treatment and prevention. Nrf2 is now a potential target for treatment, giving support to the body to fight
inflammation by acting at the cellular level.
Some studies show that activating Nrf2 can reduce fibrosis and help with lung scarring. This review shows how Nrf2 works in pulmonary fibrosis and how it might be used to develop new therapies.
Nrf2 seems to control many protective genes that fight
inflammation, oxidative stress, and other processes
involved in pulmonary fibrosis.
Transcription factor Nrf2 as a potential therapeutic target for COVID-19
Researchers Are Studying Whether Nrf2 Activators Could Be Used To Treat Viral Infections Such as COVID-19
Nrf2, or nuclear factor erythroid 2-related factor 2, is a transcription factor that plays a critical role in cellular protection and longevity. It is activated by various cellular stresses, such as oxidative stress, electrophilic
stress, and inflammation.
Emerging evidence from clinical practice suggests that Nrf2 signaling suppression is probably associated with COVID-19 pathogenesis. Lung biopsies from COVID-19 patients have revealed that genes involved in Nrf2 signaling are highly suppressed.
Additionally, levels of Nrf2 are significantly decreased in pediatric patients with SARS-CoV-2 infection. Therefore, it is hypothesized that increasing Nrf2 could be a therapeutic strategy for COVID-19.
Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways
in Drug-Induced Toxicity
Manipulating Nrf2 and NF-κB Signaling: A Promising Frontier for Safeguarding Against Drug-Induced Toxicity.
Many drugs, like overuse of APAP (Acetaminophen) and cancer treating agents, can harm organs, limiting their use in clinical treatment. We don’t fully understand how these drugs damage tissues or how to protect against it.
There’s growing interest in the Nrf2, the master antioxidant switch,
and NF-κB, a protein associated with inflammatory reactions,
signaling pathways in this context.
This text discusses how imbalances in Nrf2 and NF-κB can worsen toxicity related to such drugs. Some botanical substances such as quercetin and curcumin can restore Nrf2 activity, reducing harm and inflammation caused by NF-κB. Targeting this balance with botanical components looks promising for treating drug-induced toxicity in the future.
Redox changes in obesity, metabolic syndrome, and diabetes
Obesity, metabolic syndrome, and diabetes are redox diseases
"Life is an instantaneous encounter of circulating matter and flowing energy" (Jean Giaja, Serbian physiologist), is one of the most elegant definitions not only of life but the relationship of redox biology and metabolism. Their evolutionary liaison has created inseparable yet dynamic homeostasis in health, which, when disrupted, leads to disease.
This interconnection is even more pertinent today, in an era of increasing metabolic diseases of epidemic proportions such as obesity, metabolic syndrome, and diabetes. Despite great advances in understanding the molecular mechanisms of redox and metabolic regulation, we face significant challenges in preventing, diagnosing, and treating metabolic diseases.
The etiological association and temporal overlap of these syndromes present significant challenges for the discrimination of appropriate clinical biomarkers for diagnosis, treatment, and outcome prediction. These multifactorial, multiorgan metabolic syndromes with complex etiopathogenic mechanisms are accompanied by disturbed redox equilibrium in target tissues and circulation.
Free radicals and reactive species are considered both a causal factor and a consequence of disease status. Thus, determining the subtypes and levels of free radicals and reactive species, oxidatively damaged biomolecules (lipids, proteins, and nucleic acids) and antioxidant defense components as well as redox-sensitive transcription factors and fluxes of redox-dependent metabolic pathways will help define existing and establish novel redox biomarkers for stratifying metabolic diseases.
This review aims to discuss diverse redox/metabolic aspects in obesity, metabolic syndrome, and diabetes, with the imperative to help establish a platform for emerging and future redox-metabolic biomarkers research in precision medicine. Future research warrants detailed investigations into the status of redox biomarkers in healthy subjects and patients, including the use of emerging 'omic' profiling technologies (e.g., redox proteomes, lipidomes, metabolomes, and transcriptomes), taking into account the influence of lifestyle (diet, physical activity, sleep, work patterns) as well as circadian ~24h fluctuations in circulatory factors and metabolites.
The Role of Natural Antioxidant Products That Optimize Redox Status in the Prevention and Management of Type 2 Diabetes
The worldwide prevalence of type 2 diabetes (T2D) and prediabetes is rapidly increasing, particularly in children,
adolescents, and young adults.
The worldwide prevalence of type 2 diabetes (T2D) and prediabetes is rapidly increasing, particularly in children, adolescents, and young adults. Oxidative stress (OxS) has emerged as a likely initiating factor in T2D. Natural antioxidant products may act to slow or prevent T2D by multiple mechanisms, i.e., (1) reducing mitochondrial oxidative stress, (2) preventing the damaging effects of lipid peroxidation, and (3) acting as essential cofactors for antioxidant enzymes.
Natural antioxidant products should also be evaluated in the context of the complex physiological processes that modulate T2D-OxS such as glycemic control, postprandial OxS, the polyol pathway, high-calorie, high-fat diets, exercise, and sleep.
Minimizing processes that induce chronic damaging OxS and maximizing the intake of natural antioxidant products may provide a means of preventing or slowing T2D progression. This "optimal redox" (OptRedox) approach also provides a framework in which to discuss the potential benefits of natural antioxidant products such as vitamin E, vitamin C, beta-carotene, selenium, and manganese.
Although there is a consensus that early effective intervention is critical for preventing or reversing T2D progression, most research has focused on adults. It is critical, therefore, that future research include pediatric populations.
Nrf2, The Master Regulator Of Anti-Oxidative Responses
Nrf2 plays a crucial role in inflammation by helping our body produce antioxidants.
Nrf2 acts as a regulator and can turn on/off certain genes when needed, helping to detoxify and protect against harmful substances
The nuclear factor erythroid 2-like 2 (Nrf2) is a key factor in maintaining a balanced immune response and avoiding chronic inflammation.
When oxidative stress occurs, Nrf2 becomes stabilized and triggers the production of antioxidants and cytoprotective genes.
This leads to an anti-inflammatory response and promotes healing. Both overactivation and underactivation of Nrf2 can contribute to the development of chronic diseases.
Understanding how Nrf2 is regulated and how it interacts with signaling pathways involved in inflammation can help in developing therapies to prevent Nrf2 dysregulation and improve chronic inflammatory diseases.
Short Overview Of ROS As Cell Function Regulators And Their
Implications In Therapy Concepts.
It is important to maintain a balanced redox mediator environment for optimal cellular functioning as a
potential therapeutic target for healing and regeneration.
Reactive oxygen species (ROS) are molecules generated during normal cellular processes that can act as regulators of cellular functions. ROS play a dual role in affecting cell function and acting as mediators in various biological pathways. It is crucial to maintaining a balance in ROS levels within cells, as excessive ROS production can lead to oxidative stress and damage to cellular components.
Controlled, and localized ROS generation is essential for normal cellular processes, including cell proliferation, differentiation, apoptosis, immune responses, and others. Therapeutic strategies can modulate ROS levels to achieve desired outcomes.
For example, some therapies aim to enhance ROS production in cancer cells to induce selective cytotoxicity. Conversely, antioxidant-based therapies target excessive ROS levels to alleviate oxidative stress-related diseases and inflammation. Targeting ROS signaling pathways may hold promise for developing novel immunotherapies.
Overall, the article underscores the complex and intricate role of ROS as cell function regulators. Understanding the mechanisms by which ROS influence cellular processes can lead to the development of innovative therapeutic approaches for various diseases.
Oxidative Stress: Harms And Benefits For Human Health
Oxidative Stress: Harms and Benefits:
Oxidative stress is a phenomenon caused by an imbalance of oxygen reactive species (ROS) in cells and tissues.
ROS play several physiological roles (i.e., cell signaling), and they are normally generated as by-product of oxygen metabolism; despite this, environmental stressors (i.e., UV, ionizing radiations, pollutants, and heavy metals) contribute to greatly increase ROS production, therefore causing the imbalance that leads to cell and tissue damage.
Several antioxidants, such as vitamin E, flavonoids, and polyphenols have been exploited in the past for their supposed beneficial effect against oxidative stress. While we tend to describe oxidative stress as being harmful to the human body, it is used as a therapeutic treatment for conditions such as cancer with varying success.
This review article lays out the most recent findings in the oxidative stress field, highlighting both its bad and good sides for human health.
Hydrogen Peroxide As A Signal For Skeletal Muscle Adaptations To Exercise: What Do Concentrations Tell Us About Potential Mechanisms?
Hydrogen peroxide plays a crucial role in cell signaling, triggering positive changes in
muscle strength and endurance during exercise.
Hydrogen peroxide helps send signals for various processes, such as making our muscles stronger and more efficient during exercise.
When we exercise, our muscles undergo positive changes like increased strength and endurance that are triggered by reactive oxygen species (ROS) i.e., hydrogen peroxide.
At first, it was believed ROS were harmful, but now we know they play a vital role in signaling and regulating processes within our bodies.
This article suggests that hydrogen peroxide, an ROS, is essential for the positive adaptations in our muscles.
Redox Regulation, Gene Expression And Longevity
Mild oxidative stress may not be a factor limiting longevity.
Changes in genetics and the environment can make organisms like nematodes live longer. In a particular worm called C. elegans, being exposed to low radiation, short-term heat, and high oxygen levels has been shown to extend their lifespan, likely because they adapt to tough conditions.
This suggests that mild oxidative stress might lead to adaptations that contribute to an organism’s resilience and consequently can have a positive effect on lifespan.
NRF2, A Transcription Factor For Stress Response And Beyond
NRF2 plays a vital role in controlling a complex network of functions. Ranging from how our cells process food for energy, to the adept handling of stress.
Nrf2 (nuclear factor erythroid 2-related factor 2) transcription factor is a key player in the homeostasis process as one of the primary regulators of cellular response to environmental stressors, such as toxins and oxidative stress.
Homeostasis, which is the ability to maintain a stable internal environment despite external changes, is crucial to the health and survival of all organisms.
Further understanding of homeostasis has led to extensive research into NRF2’s role in cancer prevention and treatment, as well as inflammation and metabolism, demonstrating its functions are more far-reaching
than initially thought.
Hence, a deeper comprehension of NRF2’s regulatory
activities and its emerging roles open new opportunities for
disease therapeutics.
Telomeres And Age-Related Disease: How Telomere Biology
Informs Clinical Paradigms
Understanding how telomeres work and their impact on our cells’ health has the potential to revolutionize medical practices.
Telomeres, a structure involved in protecting the ends of chromosomes, have become crucial in understanding age-related disorders.
With recent advancements in science, researchers have been developing new treatments for varying conditions related to telomere length.
Researchers use telomere length measurements as diagnostic tools for identifying genetic disorders.
This knowledge enhances clinicians’ understanding of disease mechanisms and refines patient care. Future research on telomere biology holds promise for providing further insights into age-related diseases, leading to improved healthcare and treatment possibilities.
Oxidative Shifts in Glutathione & Redox Status in the Brain
The increasing prevalence of dementia and neurodegenerative disorders, as well as physical
impairments such as the decrease in agility and mobility, witness to the life-altering effects that
changes in brain and spinal cord have in our lives and upon our society.
The brain is sensitive to oxidative damage. Oxidative stress is particularly active in the brain and nerve tissues of the body, and are involved in numerous cellular functions including cell death and survival. The naturally high metabolic rate inherent in brain cells makes it an ideal target for oxidative attack, made worse by the fact of its (the brain’s) high lipid content and lower regenerative capacity (i.e. lower antioxidant capacity) compared with other tissues of the body. This means brain and nerve tissues are particularly vulnerable to effects of toxicity, radiation, hypoxia, nutrition stress, and compromised immune system.
Decreases in glutathione activity with age in areas of the brain and within cerebrospinal fluid over time, is what leads many researchers to say that oxidative damage is what seriously contributes to an aging brain and the worsening presence of neurodegenerative diseases. This is all due to the changing redox status in brain and nerve tissue and the cumulative effect of unregulated oxidative stress.
Oxidative shifts in glutathione and redox status are associated with cellular dysfunction, and correlated with aging-related pathophysiological processes. All this play key roles in various conditions which limit human life span.
Defense and maintenance of nerve cells against oxidative damage is essential for maintaining the functioning and viability of brain cells and nerves. The functioning presence of antioxidants is critical for neuronal protection and viability. Improved redox signaling that activates antioxidant gene signaling and protects cells from free radical injury (mitochondrial dysfunction, metals, etc), along with other gene signaling enhancements, help maintain the health of the brain, spinal cord, neuron synapse functioning, and protects from the age-related effects of accumulated oxidative damage to proteins, lipids, and DNA.
Once again, by connecting the dots between basic redox biology and metabolic processes implicit in healthy brains and bodies, we find supporting evidence for the wisdom in healthy lifestyles and appropriate supplementation of anything that supports healthy redox signaling and redox homeostasis in the body.
https://www.intechopen.com/books/5176
Epigenetics And Aging
Environmental factors such as stress and diet can impact our epigenome, which in turn affects the aging process.
Epigenetic changes play a significant role in the aging process affecting various aspects of our genome. These changes alter the accessibility of genetic material, leading to disease and decreasing longevity.
Lifespan is largely influenced by epigenetic factors rather than being solely determined by genetics. Environmental factors, including diet and stress, can impact lifespan through changes in our epigenetic information.
Overall, understanding aging mechanisms and the reversible nature of epigenetic changes offers promising possibilities for developing therapies to target aging and related diseases.
Dr Lee Ostler
“The discovery of Redox Signaling, is one of the most important medical breakthroughs of our lifetime.
"The Redoxome is the newest thing in healthcare, wellness and antiaging! Redox molecules are the deepest signaling messengers ever discovered. They control all cellular health functions. They live at the interface of energy and matter where life’s energy is created and used to activate cellular communication, biological programming, cell renewal and metabolic health. Activating them in a redox lifestyle turns on healthy pathway genes and nature's healing powers inside every cell of your body.
This is how to Awaken Your Inner Doctor!"
– Dr Lee Ostler, Author of Redox Matters
To take DEEP DIVE into Redox Biochemistry, click on the video for Health Professionals below
ASEA’s Redox Supplement
More and more, people around the world are hearing about an exciting, relatively new company called ASEA and the flagship product that bears the same name. What is ASEA, and what is unique about this company and product that are receiving so much international interest?
ASEA the Company
ASEA LLC is an emerging global leader in developing, manufacturing, and marketing high-quality cellular health products. ASEA officially launched in 2010 with its inaugural product based on cutting-edge technology known as redox signaling. The launch of ASEA Redox Supplement was so well received by consumers that the company was able to build a multimillion-dollar global enterprise based on this single product. Subsequently, in 2014, the company introduced RENU 28, a revitalizing whole-body skin gel that also leverages the benefits of redox signaling molecules topically. Since its launch, ASEA has enjoyed burgeoning success and today operates in 33 international markets. The goal of ASEA founders and executives is to continue to push the boundaries of what’s possible in the cellular health category, developing and marketing products that address global megatrends towards natural solutions to individuals’ overall health and wellness.
ASEA the Products
ASEA’s original product, known as ASEA Redox Supplement, is classified as a dietary supplement in the United States. It is unlike any other dietary supplement in that its uniqueness isn’t based on ingredients like herbs, botanicals, exotic fruits and berries, or complex vitamin and mineral formulations. Rather, ASEA Redox Supplement’s uniqueness stems from the fact that it contains redox signaling molecules—molecules that are native to the body and vital for life. These crucial molecules act as cellular message carriers, helping to protect, rejuvenate, and keep cells functioning at optimal levels.
ASEA has created and patented technology that restructures salt and water to produce a redox molecule supplement that supports biological processes already within the body. This proprietary process results in a natural form of chlorine that some consumers can taste despite its low, safe level. ASEA® REDOX Cell Signaling Supplement is produced in an FDA-registered, NSF-certified facility and is certified by independent third-party laboratories to contain redox signaling molecules.
PATENT PROTECTED
There is a big difference between “patent pending” and having actual patents filed and accepted by the US Patent Office! The ASEA REDOX and RENU 28 technology is currently protected by the many active patents, and over 200 trade secrets covering all aspects of the manufacturing process.
REDOX Certification
ASEA REDOX Cell Signaling Supplement and RENU28 Redox Gel, are produced in an FDA-registered, NSF-certified facility. Every batch is rigorously tested in-house. However, to further validate internal testing, we have established partnerships with sophisticated and accredited chemical-analytical laboratories.
These third-party labs offer a wide catalog of assay kits and electrochemical devices, to help us measure multiple redox parameters. Their teams include chemists, biotechnologists, and biologists, with industrial and postdoctoral experience. They monitor and analyze data markers, such as total antioxidant capacity (TAC), enzymatic activity, phenolic compounds, and reactive oxygen species (ROS).
ASEA Redox Safety Study
ASEA commissioned Pacific Northwest National Laboratory to study the toxicity response of eukaryotic cells, when in contact with ASEA Redox Supplement. Eukaryotic cells contain an array of cellular structures that play important roles in energy balance, metabolism, and gene expression.
It was shown that direct exposure of cells to relatively high concentrations of ASEA Redox Supplement (the equivalent to replacing 20% of a blood plasma solution with ASEA Redox), did not register a significant toxic response, as measured by nuclear translocation.
Based on these results, ASEA Redox Supplement, orally administered, does not manifest a toxic or inflammatory response to exposed tissue.
While the science of redox signaling is relatively new and ASEA is just a few years old, the company has pursued a strategic research agenda to validate the product. The first strategy was to determine its safety, which was confirmed in a 12-week trial with more than 100 participants.
Once safety was confirmed, ASEA has pursued a number of studies to validate the efficacy of its products.
While the science behind ASEA’s redox signaling technology may seem new to some, it is gaining attention from researchers and has been the subject of tens of thousands of peer-reviewed scientific papers.
As research catches up with the groundbreaking nature of ASEA’s technology redox signaling it will take its place among some of the most significant scientific breakthroughs of the late 20th century
Studies show 40% INCREASE in Glutathione
using ASEA Redox Supplement & Gel
The investigation into the role of redox signaling molecules (RSM) in AREc32 and HepG2 cells, as well as FEK4 cells, has yielded insightful findings regarding their impact on pathways that protect cells from oxidative stress. The experiments provided understanding of Nrf2 cellular responses to RSM and also demonstrated the capability of RSM to upregulate glutathione production on the cells.
The results indicated that RSM containing in V10, induces a mild yet discernible activation of the Nrf2 pathway in AREc32 and HepG2 cells, contributing to cellular defense against oxidative stress. The consistent Nrf2 activation across different sample lots, as verified by independent laboratories, strengthens the reliability of our findings. Additionally, the investigation into Nrf2-regulated antioxidant potential revealed increased expressions of GCLC and HO-1, suggesting a cellular adaptive response to enhance antioxidant capacity.
Furthermore, our exploration extended to FEK4 cells, where redox signaling molecules demonstrated no cell toxicity or impairment on cell viability. Results showed that RSM were able to increase and/or restore intracellular glutathione levels, after BSO treatment, as well as promoting Nrf2 translocation to the nucleus. These observations suggest the potential of RSM in supporting cellular health and antioxidant defense mechanisms.
The positive results obtained from different cell lines and assays have provided a comprehensive perspective on the multifaceted impact of redox signaling molecules on cellular functions. These findings contribute to the growing body of knowledge in the field of redox signaling and may pave the way for further studies to unravel the underlying pathways involved in RSM response to cellular stress.
These studies demonstrated consistent and promising results connecting the role of RSM to cellular resilience and antioxidant defense.
As a matter of fact, this research may set the stage for future investigations, potentially leading to the development of innovative approaches for cellular health enhancement and oxidative stress management.
Reduction in Oxidized LDL Cholesterol
In a double-blind placebo study conducted by David C. Nieman, DrPH, FACSM, of Appalachian State University, 106 women consumed four ounces of ASEA Redox Supplement per day for 90 days.
The results showed significant results with study participants experiencing
reduced oxidative stress biomarkers. *
In particular, they experienced a 6.3% lowering of the oxidized form of LDL cholesterol, suggesting that ASEA Redox Supplement may help reduce oxidative stress and support cardiovascular health.
*ASEA Redox Supplement ingestion over 12 weeks was associated with lower 8-hydroxydeoxyguanosine (8-OHdG), an oxidized nucleoside of DNA and biomarker of generalized, cellular oxidative stress.
800% Increase in Glutathione Efficacy
Researchers at the Pacific Northwest National Laboratory (PNNL) performed in vitro tests to determine the antioxidant efficiency of the body’s most powerful natural antioxidant enzymes glutathione peroxidase (GPx) and superoxide dismutase (SOD).
The results showed significant, well-defined effects.
The cell extracts exposed to ASEA Redox Supplement exhibited 8 times the antioxidant efficiency for GPx, and 5 times antioxidant efficacy for SOD. This efficiency was evident especially at low-level concentrations of ASEA Redox Supplement, tested down to 2.5% of full strength.
Improved Apoptosis of Stressed Cells
Cachexia, a group of proteins, is usually secreted to instigate cell death in damaged or dysfunctional tissues, allowing surrounding healthy cells to divide and fill in voids. Thus, increasing the sensitivity to cachexin in dysfunctional cells, may help accelerate such a process.
In this experiment, cell cultures with normal random cell cycles and cultures approaching confluence (end-of-life), received increasing concentrations of cachexin stressor.
Exposure to ASEA Redox Supplement caused no significant change in the response of the normal random cycling cells to cachexin.
However, cultures approaching confluence (end of life cycle) exposed to ASEA Redox Supplement exhibited increased sensitivity to cachexin, restoring behavior comparable to that of normal cells.
Up to 31% Increase in Gene Expression
In a randomized double-blind placebo-controlled study, 60 participants were divided into three groups, 25 in the active group (ASEA REDOX), 25 in the placebo group (saline placebo), and 10 in the control group (did not drink either ASEA REDOX or placebo). It is important to note that the placebo was the same saline used to create the ASEA REDOX for this study but did not contain ASEA’s patented redox molecules.
(Editor’s Note: The positive results of ASEA REDOX, over the saline solution that ASEA is made from, should be considered definitive proof, even for the most dedicated skeptic, that ASEA is NOT a bottle of salt water, despite being made from salt and water)
Each participant, except for the control group, drank 4 ounces of ASEA REDOX or placebo twice daily. Participants’ blood was drawn at week zero and at week eight.
Results showed a 20 – 31% difference in gene expression abundance in five genes that play a vital role in five human health areas; Immune Function, Inflammatory Response, Cardiovascular Health, Digestive Health and Hormone Modulation.
These genes are also involved in dozens of other pathways that also positively impact many other areas of human health.